Ipamorelin Dosage, Protocol, and Reconstitution Guide

Ipamorelin

Ipamorelin is a selective growth hormone secretagogue that stimulates natural GH release without significantly increasing cortisol or prolactin, making it one of the cleanest and most tolerable GH peptides.

How It Works

Ghrelin Receptor Activation → GH Pulse ↑ → IGF-1 ↑ → Recovery + Fat Loss + Lean Mass

Ipamorelin binds to the ghrelin receptor (GHSR-1a), triggering a short, natural pulse of growth hormone. Its high selectivity allows GH release without major impact on other hormones.

Ipamorelin is one of the most selective GH secretagogues.

It is commonly used for recovery, sleep support, and body composition.

It does not significantly raise cortisol or prolactin like other GHRPs.

Often used as a foundation peptide in GH-based stacks.

Ipamorelin Protocol

10 mg vial + 3.0 mL BAC Water → 1 unit = 33 mcg → Clean GH Pulse + Recovery Support

Standard Setup

Vial10 mg

Water3.0 mL bacteriostatic water

Concentration3.33 mg/mL

Conversion1 unit = 33.3 mcg

Weeks 1–2

Start Phase

Dose100 mcg

Units3 units

Volume0.03 mL

Weeks 3–4

Build Phase

Dose150 mcg

Units5 units

Volume0.05 mL

Weeks 5–8

Performance Phase

Dose200 mcg

Units6 units

Volume0.06 mL

Weeks 9–12

Higher Range

Dose250 mcg

Units8 units

Volume0.08 mL

Protocol Details

FrequencyOnce daily

Timing30–60 min before bed (fasted)

Cycle Length8–12 weeks

Extended UseUp to 16 weeks (with break)

Simple structure

Ipamorelin is typically run as a clean, consistent nightly GH pulse. Fasted dosing before sleep is the most common and simplest structure.

Advanced Protocol

Higher Range

Advanced

Dose200–300 mcg daily

Split Dosing Option

AM + PM dosing may increase total GH signaling

PM dose still prioritized for sleep-related GH pulse

More advanced and not required for most users

Advanced Use

Most users do not need split dosing. Once-daily bedtime use provides a clean and effective GH pulse with fewer variables.

How to Use Ipamorelin (Timing & Injection)

Injection TypeSubcutaneous

Timing30–60 minutes before bed

Fasted StateRecommended

Best Practices

Avoid food 2–3 hours before injection if possible

Inject consistently at the same time nightly

Rotate injection sites (abdomen, thigh, upper arm)

Keep routine consistent for stable GH signaling

Reconstitution & Dosing (10 mg Vial)

Vial10 mg

Water3.0 mL

Concentration3.33 mg/mL

Conversion1 unit = 33 mcg

Dose Reference

3 units ≈ 100 mcg

5 units ≈ 165 mcg

6 units ≈ 200 mcg

8 units ≈ 265 mcg

9 units ≈ 300 mcg

Reconstitution Steps

Draw 3.0 mL bacteriostatic water

Inject slowly down vial wall

Gently swirl (do not shake)

Allow peptide to fully dissolve

Refrigerate immediately after mixing

Storage & Shelf Life

Lyophilized (Unmixed)

Store refrigerated (2–8°C) for regular use

Freeze at −20°C (−4°F) for long-term storage

Keep sealed, dry, and protected from light

Avoid heat, moisture, and repeated temperature changes

Estimated shelf life: ~12–24 months refrigerated, longer if frozen

Reconstituted (Mixed)

Refrigerate at 2–8°C (36–46°F)

Do not freeze after mixing

Use within ~30 days for best stability

Avoid shaking or agitation

Discard if cloudy, discolored, or particles appear

Best Practice

Handling

Keep handling consistent and minimize exposure to air, heat, and light. Always use sterile technique when drawing doses.

Temperature

Return vial to the refrigerator immediately after use. Avoid leaving at room temperature for extended periods.

Stability Insight

Ipamorelin is moderately stable compared to some peptides, but maintaining cold storage helps preserve potency and consistent GH signaling over time.

Cycle Length & Time Between Cycles

GH Support Phase → Reset → Reassess → Repeat

Cycle Length

Standard8–12 weeks

ExtendedUp to 16 weeks

Time Between Cycles

Break2–4 weeks

Helps maintain receptor sensitivity

Prevents diminishing returns

Allows reassessment of sleep and recovery

Monitoring During Use

Sleep quality improvements

Recovery and soreness reduction

Body composition changes

IGF-1 levels (longer cycles)

Benefits

Increased natural GH release

Improved recovery and repair

Enhanced fat metabolism

Lean muscle support

Minimal hormonal side effects

Potential Side Effects

Mild injection site irritation

Headache (rare)

Temporary hunger increase

Water retention (rare)

Stacking Strategies

Clean GH Pulse → Layered Support → Recovery + Composition

Common Stacks

Best Stack: Ipamorelin + CJC-1295 (NO DAC)

Recovery: Ipamorelin + BPC-157

Advanced: Add IGF-1 (experienced users)

Important Notes

Highly selective GH release (no cortisol spike)

Short half-life (~2 hours)

Works best fasted

Cycle to maintain sensitivity

Important Disclaimer

Ipamorelin is not FDA-approved and is intended for research purposes only.

Ipamorelin Guide → Peptide Directory →